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Range where the density estimate of the cancer in question was highest, we calculated the area between it and the next highest density estimate, regardless of what cancer type it represented (additional file 1). Since all density estimates had their area normalized to 1, this procedure resulted in a number between 0 and 1, and represents the uniqueness of that gene's expression pattern in that cancer type when compared to all other cancer types. buy viagra without prescription Gene weight application gene weights were applied as follows. When calculating the final similarity score between a test sample and a cancer type (mean of the ts-scores for each gene for that cancer type), each gene's ts-score was multiplied by the weight that gene had for the cancer type in question. buy online viagra The resulting ts-scores were then divided by the mean of all gene weights for that cancer type. generic viagra from india review This was done to normalize the different amounts of specific genes different cancer types possess. viagra online without prescription Finally, the similarity score between the test sample and the cancer type was calculated by taking a mean of the ts-scores. The workflow is depicted in additional file 1. Reference database reference data, both expression values and annotation, were fetched from the genesapiens database [23]. The cancer data consisted of 5,577 samples that were grouped into 56 cancer types (additional file 2). The healthy tissue reference data were the same as used in [22], consisting of 1,667 samples representing 44 tissue types. Test data the test data were from geo [21] study {"type":"entrez-geo","attrs":{"text":"gse12630","term_id":"12630"}}gse12630. generic viagra without prescription They were transformed to be compatible with the genesapiens database by using mas5 and the equalization transformation as described previously [23,24]. Array-generation-based gene centering (agc) was performed using the gene and array generation specific correction factors used to construct the genesapiens database. Data analysis all data analysis was done with r [25]. medicaresupplementspecialists.com/pfz-cheap-viagra-online-no-rx-yl/ Accuracy versus best similarity score the test samples were arranged according to the highest similarity score they had attained for any cancer, and whether this cancer was a correct classification was also recorded. From this, the fractions with the highest score above a certain threshold were trivial to calculate. generic viagra from india review A graph showing accuracy as a function of the highest similarity score was calculated using a sliding window. The width of the window was 0. risks viagra young men 1 (in similarity units) and it was moved in steps of length 0. generic viagra rx 005 over the ordered test sample population. youtube viagra song The perce.
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